Search results for "methods [DNA Mutational Analysis]"

Stochastic analysis of dynamical systems with delayed control forces

2006

Abstract Reduction of structural vibration in actively controlled dynamical system is usually performed by means of convenient control forces dependent of the dynamic response. In this paper the existent studies will be extended to dynamical systems subjected to non-normal delta-correlated random process with delayed control forces. Taylor series expansion of the control forces has been introduced and the statistics of the dynamical response have been obtained by means of the extended Ito differential rule. Numerical application provided shows the capabilities of the proposed method to analyze stochastic dynamic systems with delayed actions under delta-correlated process contrasting statist…

Burst analysis tool for developing neuronal networks exhibiting highly varying action potential dynamics

2012

In this paper we propose a firing statistics based neuronal network burst detection algorithm for neuronal networks exhibiting highly variable action potential dynamics. Electrical activity of neuronal networks is generally analyzed by the occurrences of spikes and bursts both in time and space. Commonly accepted analysis tools employ burst detection algorithms based on predefined criteria. However, maturing neuronal networks, such as those originating from human embryonic stem cells (hESC), exhibit highly variable network structure and time-varying dynamics. To explore the developing burst/spike activities of such networks, we propose a burst detection algorithm which utilizes the firing s…

Modelling thermionic emission by using a two Level mechanical system

2008

The Boltzmann factor is at the basis of a great amount of thermodynamic and statistical physics, both classical and quantum. It describes the behaviour of natural systems that exchange energy with the environment. However, why does the expression have that specific form? The Feynman Lectures on Physics justifies it heuristically by referencing to the "exponential atmosphere" example. Thermodynamics textbooks usually give a more or less complete explanation that mainly involves a mathematical analysis, where it is hard to see the logic flow. Moreover, the necessary mathematics is not at the level of high school or college students' preparation. Here we present an experiment and a simulation …

Comparison of some dispersion-corrected and traditional functionals as applied to peptides and conformations of cyclohexane derivatives.

2012

We compare the energetic and structural properties of fully optimized α-helical and antiparallel β-sheet polyalanines and the energetic differences between axial and equatorial conformations of three cyclohexane derivatives (methyl, fluoro, and chloro) as calculated using several functionals designed to treat dispersion (B97-D, ωB97x-D, M06, M06L, and M06-2X) with other traditional functionals not specifically parametrized to treat dispersion (B3LYP, X3LYP, and PBE1PBE) and with experimental results. Those functionals developed to treat dispersion significantly overestimate interaction enthalpies of folding for the α-helix and predict unreasonable structures that contain Ramachandran φ and …

TWJ-Screen: an isothermal screening assay to assess ligand/DNA junction interactions in vitro

2017

International audience; The quest for chemicals able to operate at selected genomic loci in a spatiotemporally controlled manner is desirable to create manageable DNA damages. Mounting evidence now shows that alternative DNA structures, including G-quadruplexes and branched DNA (or DNA junctions), might hamper proper progression of replication fork, thus triggering DNA damages and genomic instability. Therefore, small molecules that stabilize these DNA structures are currently scrutinized as a promising way to create genomic defects that cannot be dealt with properly by cancer cells. While much emphasis has been recently given to G-quadruplexes and related ligands, we report herein on three…

An update to Hippocampome.org by integrating single-cell phenotypes with circuit function in vivo.

2021

Understanding brain operation demands linking basic behavioral traits to cell-type specific dynamics of different brain-wide subcircuits. This requires a system to classify the basic operational modes of neurons and circuits. Single-cell phenotyping of firing behavior during ongoing oscillations in vivo has provided a large body of evidence on entorhinal–hippocampal function, but data are dispersed and diverse. Here, we mined literature to search for information regarding the phase-timing dynamics of over 100 hippocampal/entorhinal neuron types defined in Hippocampome.org. We identified missing and unresolved pieces of knowledge (e.g., the preferred theta phase for a specific neuron type) a…

Cruise passengers' expenditure at destinations: Review of survey techniques and data collection

2020

Spending by cruise passengers constitutes an important contribution to the economy of destinations. The issues related to the analysis of the expenditure have been widely debated for many years both in the scientific literature and in the common political debate. Despite 20 years of empirical research on this topic, not consolidated quantification methods exist to inform the debate. This work offers a brief review of the principal research on cruise tourist spending. It analyses the main characteristics of the surveys, reviews the different methods and techniques employed as well as assesses the main results. The article concludes with a discussion of the studies conducted and identifies fu…

Lidar : traitement avancé des données et interprétation archéologique - cours 2016

2016

Les déterminants des compétences sociales des élèves de cycle III

2016

Les différences de réussite à l’école primaire traditionnellement étudiées par les chercheurs en éducation peuvent être analysées à la lumière des compétences et plus particulièrement des compétences sociales. Champ théorique encore en construction, les compétences sociales deviennent tout de même un « incontournable » pour les acteurs du système éducatif et pour la recherche en sciences de l’éducation. Par une approche pluridisciplinaire, cet article propose d’étudier quels sont les déterminants des compétences sociales à l’aide d’indicateurs sociodémographiques et scolaires largement empruntés dans les modèles d’explication des différences de réussite, auxquels sont associées des mesures …

The MOBI-Kids Study Protocol: Challenges in Assessing Childhood and Adolescent Exposure to Electromagnetic Fields from Wireless Telecommunication Tec…

2014

The rapid increase in mobile phone use in young people has generated concern about possible health effects of exposure to radiofrequency (RF) and extremely low frequency (ELF) electromagnetic fields (EMF). MOBI-Kids, a multinational case–control study, investigates the potential effects of childhood and adolescent exposure to EMF from mobile communications technologies on brain tumor risk in 14 countries. The study, which aims to include approximately 1,000 brain tumor cases aged 10–24 years and two individually matched controls for each case, follows a common protocol and builds upon the methodological experience of the INTERPHONE study. The design and conduct of a study on EMF exposure an…